Publications And Projects

Evaluation of recombinant human IGF-1/IGFBP-3 on intraventricular hemorrhage prevention and survival in the preterm rabbit pup model

Claes Ekström , Niklas Ortenlöf , Amanda Kristiansson , Bo Holmqvist , Åsa Jungner , Suvi Vallius , Xiaoyang Wang , Ann Hellström , Norman Barton , Galen Carey , David Ley, Magnus Gram

Evaluation of enhanced permeability effect and different linear energy transfer of radionuclides in a prostate cancer xenograft model

Oskar Vilhelmsson Timmermand, Marcella Safi, Bo Holmqvist and Joanna Strand

Co-injection of anti-HER2 antibody Trastuzumab does not increase efficacy of [¹⁷⁷Lu]Lu-PSMA-617 therapy in an animal model of prostate cancer

Ayman Abouzayed, Wahed Zedan, Mohamed Altai, Joanna Strand and Anders Örbom

Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3

Niklas Ortenlöf, Suvi Vallius, Helena Karlsson, Claes Ekström, Amanda Kristiansson, Bo Holmqvist, Olga Göransson, Magdaléna Vaváková, Martin Rydén, Galen Carey, Norman Barton, David Ley and Magnus Gram

Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs

Line I. Christiansen, Gemma C. Ventura, Bo Holmqvist, Karoline Aasmul-Olsen, Sandy E. H. Lindholm,
Matthew D. Lycas, Yuki Mori, Jan Bojsen-Møller Secher, Douglas G. Burrin, Thomas Thymann, Per T. Sangild and Stanislava Pankratova

Insulin-Like Growth Factor-1 Supplementation Promotes Brain Maturation in Preterm Pigs

Line I. Christiansen, Bo Holmqvist, Xiaoyu Pan, Kristine Holgersen, Sandy E. H. Lindholm, Nicole L. Henriksen, Douglas G. Burrin, David Ley, Thomas Thymann, Per Torp Sangild, and Stanislava Pankratova

Experimental in vivo model to evaluate the impact of Cernitin™ on pain response on induced chronic bladder inflammation

Céline Augé, Nishtman Dizeyi, Lena Ramnemark, Philippe Lluel and Magnus Grabe

Reversible Self-AssemblReversible Self-Assembled Monolayers with Tunable Surface Dynamics for Controlling Cell Adhesion Behavior

Sing Yee Yeung, Yulia Sergeeva, Guoqing Pan, Silvia Mittler, Thomas Ederth, Tommy Dam, Peter Jönsson, Zahra El-Schich, Anette Gjörloff Wingren, Adam Tillo, Sabrina Hsiung Mattisson, Bo Holmqvist, Maria M. Stollenwerk, Börje Sellergren

Severe intraventricular hemorrhage causes long-lasting structural damage in a preterm rabbit pup model

Olga Romantsik, Emily Ross-Munro, Susanne Grönlund, Bo Holmqvist, Anders Brinte, Erik Gerdtsson, Suvi Vallius, Matteo Bruschettini, Xiaoyang Wang, Bobbi Fleiss and David Ley

Hydrogels and Cubic Liquid Crystals for Non-Invasive Sampling of Low-Molecular-Weight Biomarkers—An Explorative In Vivo Study

Maxim Morin, Skaidre Jankovskaja, Tautgirdas Ruzgas, Joakim Henricson, Chris D. Anderson, Anders Brinte, Johan Engblom and Sebastian Björklund

A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen
Oskar Vilhelmsson Timmermand, Anders Örbom, Mohamed Altai, Wahed Zedan, Bo Holmqvist, Marcella Safi, Thuy A. Tran, Sven-Erik Strand and Joanna Strand

Insulin-Like Growth Factor 1 in the Preterm Rabbit Pup: Characterization of Cerebrovascular Maturation following Administration of Recombinant Human Insulin-Like Growth Factor 1/Insulin-Like Growth Factor 1-Binding Protein 3
Magnus Gram, Claes Ekström, Bo Holmqvist, Galen Carey, Xiaoyang Wang Suvi Vallius, William Hellström, Niklas Ortenlöf, Alex Adusei Agyemang,
Lois E.H. Smith, Ann Hellström, Alexandra Mangili, Norman Barton, David Ley

Biodistribution of fluorescence-labelled EGF protein from slow release NanoZolid depots in mouse
Stefan Grudén, Charlott Brunmark, Bo Holmqvist, Erwin D. Brenndörfer, Martin Johansson, Jian Liu c, Ying Zhao a,e, Niklas Axén, Moustapha Hassan

Cell-free oxidized hemoglobin drives reactive oxygen species production and pro-inflammation in an immature primary rat mixed glial cell culture
Alex Adusei Agyemang, Suvi Vallius Kvist, Nathan Brinkman, Thomas Gentinetta, Miriam Illa, Niklas Ortenlöf, Bo Holmqvist, David Ley & Magnus Gram

In vivo tumor targeting of biomolecules formulated in slow release Nanozolid depots
Grudén, C. Brunmark, B. Holmqvist, E.D. Brenndörfer, M. Johansson, J. Liu, Y. Zhao, N. Axén, M. Hassan (Submitted)

Quantitative γ-H2AX immunofluorescence method for DNA double-strand break analysis in testis and liver after intravenous administration of 111InCl3
Anna Stenvall, Erik Larsson, Bo Holmqvist, Sven-Erik Strand, Bo-Anders Jönsson

Cerebellar exposure to cell-free hemoglobin following preterm intraventricular hemorrhage: causal in cerebellar damage?
Alex Adusei Agyemang, Kristbjörg Sveinsdóttir, Suvi Vallius, Snjolaug Sveinsdóttir , Matteo Bruschettini, Olga Romantsik, Ann Hellström, Lois E H Smith, Lennart Ohlsson, Bo Holmqvist, Magnus Gram, David Ley.

Application of Prussian white for visualization of H2O2 penetration through skin: in vitro model of H2O2 sensing.
Skaidre Jankovskaja, Anaïs Labrousse, Léa Prévaud, Bo Holmqvist, Anders Brinte, Johan Engblom, Melinda Rezeli, György Marko-Varga and Tautgirdas Ruzgas.

Cell-free oxidized hemoglobin drives reactive oxygen species production and pro-inflammation in a primary rat mixed glial cell culture.
Alex Adusei Agyemang, Suvi Vallius Kvist, Nathan Brinkman, Thomas Gentinetta, Miriam Illa Armengol, Niklas Ortenlöf, Bo Holmqvist, David Ley, Magnus Gram.

Long-term neurological effects of neonatal caffeine treatment in a rabbit model of preterm birth
Van der Veeken L, Grönlund S, Gerdtsson E, Holmqvist B, Deprest J, Ley D, Bruschettini M

Cerebellar Exposure to Cell-Free Hemoglobin Following Preterm Intraventricular Hemorrhage: Causal in Cerebellar Damage?
Agyemang AA, Sveinsdóttir K, Vallius S, Sveinsdóttir S, Bruschettini M, Romantsik O, Hellström A, Smith LEH, Ohlsson L, Holmqvist B, Gram M, Ley D

The heme and radical scavenger α1-3 microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage
Olga Romantsik, Alex Adusei Agyemang, Snjolaug Sveinsdóttir, Sigurbjörg Rutardóttir, Bo Holmqvist, Magnus Cinthio, Mattias Mörgelin, Gulcin Gumus, Helena Karlsson, Stefan R Hansson, Bo Åkerström, David Ley, Magnus Gram
(Journal of  Neuroinflammation)

High Presence of Extracellular Hemoglobin in the Periventricular White Matter Following Preterm Intraventricular Hemorrhage
Ley D, Romantsik O, Vallius S, Sveinsdóttir K, Sveinsdóttir S, Agyemang AA, Baumgarten M, Mörgelin M, Lutay N, Bruschettini M, Holmqvist B, Gram M.

Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival
Matilda Munksgaard Thorén, Katarzyna Chmielarska Masoumi, Cecilia Krona, Xiaoli Huang, Soumi Kundu, Linnéa Schmidt, Karin Forsberg-Nilsson, Marcus Floyd Keep, Elisabet Englund, Sven Nelander, Bo Holmqvist and Evy Lundgren-Åkerlund

Protection of kidney function with human antioxidation protein α1-microglobulin (A1M) in a mouse 177Lu-DOTATATE radiation therapy model
Kristiansson A, Ahlstedt J, Holmqvist B, Brinte Anders Tran T, Forssell-Aronsson E,
Strand S-E, Gram M, Akerstrom B
(Accepted for publication in Antioxidants & Redox Signaling)

Preterm birth and caffeine exposure – effects on the IGF-1 system and cerebellar maturation in rabbit pups.
Kristbjörg Sveinsdóttir1, Matteo Bruschettini1,2, Suvi Vallius Kvist3, Magnus Gram3, Bo Holmqvist4, David Ley1 (ISBN 978-91-7619-635-9)
Stellate cells and mesenchymal stem cells in benign mammary stroma are associated with risk factors for breast cancer – an observational study
Isfoss BL, Holmqvist B, Sand E, Forsell J, Jernström H, Olsson H.

Biodistribution and pharmacokinetics of recombinant α₁-microglobulin and its potential use in radioprotection of kidneys
Jonas Ahlstedt, Thuy A Tran, Filip Strand, Bo Holmqvist, Sven-Erik Strand, Magnus Gram, and Bo Åkerström

Stellate cells and mesenchymal stem cells in benign mammary stroma are associated with risk factors for beast cancer (Submitted) BMC Cancer Research
Björn Logi Isfoss, Bo Holmqvist, Elin Sand, Johan Forsell, Helena Jernström, Håkan Olsson

Lingonberries alter the gut microbiota and prevent low-grade inflammation in high-fat diet fed mice.
Heyman-Lindén L, Kotowska D, Sand E, Bjursell M, Plaza M, Turner C, Holm C, Fåk F, Berger K.

High Presence of Extracellular Hemoglobin in the Periventricular White Matter Following Preterm Intraventricular Hemorrhage. Front. Physiol. 7:330
Ley D, Romantsik O, Vallius S, Sveinsdottir K, Sveinsdottir S, Agyeman A, Baumgarten M, Mörgelin M, Lutay N, Bruschettini, Holmqvist B, Gram M

The absence of aldehyde dehydrogenase 1 A1-positive cells in benign mammary stroma is associated with risk factors for breast cancer. Breast Cancer – Targets and Therapy 8: 117-124.
Isfoss B, Holmqvist B, Jernström, Alm P, Olsson H

The dynamics of platelet activation during the progression of streptococcal sepsis. (Accepted) PLOS ONE
Thesis: Mediatryck, Lund, ISBN 978-91-7619-256-6.
Hurley S, Lutay N, Holmqvist B, Shannon O.

Biodistribution and pharmacokinetics of recombinant α1-microglobulin and its potential use in radioprotection of kidneys
‘Jonas Ahlstedt · Thuy A Tran · Filip Strand · Bo Holmqvist · Sven-Erik Strand · Magnus Gram · Bo Åkerström

Adenovirus assembly is impaired by BMI1-related histone deacetylase activity.
Manli Na · Dongfeng Chen · Bo Holmqvist · Liang Ran · Jie Jin · Johan Rebetz · Xiaolong Fan

Women with familial risk for breast cancer have an increased frequency of aldehyde dehydrogenase expressing cells in breast ductules.
Björn L Isfoss · Bo Holmqvist · Helena Jernström · Per Alm

Using intravital microscopy to observe bevacizumab-mediated anti-angiogenesis in human head and neck squamous cell carcinoma xenografts
Takashi Yamatodani · Bo Holmqvist · Elisabeth Kjellén · Anders Johnsson · Hiroyuki Mineta · Johan Wennerberg

Distribution of aldehyde dehydrogenase 1-positive stem cells in benign mammary tissue from women with and without breast cancer.
Isfoss BL, Holmqvist B, Alm P, Olsson H

Distribution of ALDH1 positive stem cells in benign epithelial and stromal mammary tissue from women with and without breast cancer. Histopathology [In press]
Isfoss BL, Holmqvist B, Alm P, Olsson H (2011)

Microspectroscopic Evidence of Cretaceous Bone Proteins. PLoSONE 6(4) e19445
Lindgren J, Uvdal P, Engdahl A, Lee AH, Alwmark C, Bergquist K-E, Nilsson E, Ekström P, Rasmussen M, Douglas DA, Polcyn MJ, Jacobs LL (2011)

Genetic control of acute pyelonephritis and renal scarring; dysfunctional innate immunity in mCxcr2 heterozygous mice. Kidney Int Aug 3. doi: 10.1038/ki.2011.257. [Epub ahead of print]
Svensson M, Yadav M, Holmqvist B, Lutay N, Svanborg C, Godaly G (2011)

Bevacizumab (Avastin) effects on xenografted human squamous carcinoma tumors – An intravital microscopical study in a mouse dorsal skinfold model. (Submitted).
Yamatodani T, Holmqvist B, Kjéllen E, Oh P, Johnsson A, Mineta H and WennerbergJ (2011).